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The Human Microbiome Project is expanding its scope thanks to $42 million in additional funding from the National Institutes of Health.
The National Institutes of Health today announced approximately $42 million to expand the scope of eight demonstration projects designed to link changes in the human microbiome to health and disease. The funds will also support investigators to develop innovative technologies to improve the identification and characterization of microbial communities of the human microbiome.
Release Notes for NCI HMP Foregut Microbiome in Development of Esophageal Adenocarcinoma.
The Human Microbiome Project (HMP), funded as an initiative of the NIH Roadmap for Biomedical Research (http://nihroadmap.nih.gov), is a multi-component community resource. The goals of the HMP are to demonstrate the feasibility of characterizing the human microbiome well enough to enable study of the variation in the human microbiome (with population, genotype, disease, age, nutrition, medication, and environment) and its influence on disease, while providing both a standardized data resource and technological developments to enable such studies to be undertaken broadly in the scientific community. The HMP is a limited effort per se, but has the ultimate objective of creating broad opportunities to improve human health through monitoring or manipulating the human microbiome.
The Demonstration Projects aim to tackle the most important question of the HMP: whether changes in the microbiome can be related to human health and disease. Because of the short time frame of the HMP, the primary goal of these projects is to establish a correlation between microbiome changes and health/disease, rather than demonstrate causation. If a project can successfully demonstrate correlation early in the timeline, work to begin to establish causation may be undertaken. But the HMP recognizes that such studies may take years of work to complete and go beyond the initial goals of the HMP.
While a great deal is known about disease-causing pathogens, relatively little is known about the seemingly innocuous microorganisms living in and on the body. Called the microbiome, this microbial community outnumbers the body's own cells by a factor of 10. Mounting evidence suggests the microbiome plays a bigger role in human health and disease than previously thought.
Scientist’s have long thought of the esophagus as a desolate path connecting two hubs of activity: the mouth and the stomach. But new research by
, MD, PhD, assistant professor of pathology and medicine, paints a very different picture- one of a highway teeming with millions of bacteria, harmful and beneficial alike. Zhiheng Pei
Could having the wrong bacteria give you cancer? That's the question raised by a new study by researchers at
. They found that people who have either chronic heartburn or a more serious, precancerous condition called Barrett's Esophagus had completely different kinds of microbes living in their throats that those who were healthy. NYU Langone Medical Center
Gastroesophageal reflux disease is on the rise in the
and associated with large scale changes in the microbes living in your esophagus. The changes are drastic enough that a normal "microbiome" can be defined and another that is 15 times more likely to be found in people with esophagitis or Barrett's Esophagus, according to US Zhiheng Pei, MD, PhD, of . NYU Langone Medical Center
Gastroesophageal reflux diseases, or GERD, affects about 10 million people in the
, yet the cause and an unexpected increase in its prevalence over the last three decades remains unexplainable. Now, researchers have discovered that GERD is associated with global alteration of the microbiome in the esophagus. The findings, reported in the August 1, 2009 issue of Gastroenterology, may provide for the foundation for further study of the condition as a microecological disease with new treatment possibilities. United States
researchers have received $1,560,000 in grant support for their first year of studies focused on microbiome and psoriasis and on microbiome and esophageal cancer from the National Institutes of Health (NIH). The studies being conducted at NYU Langone Medical Center are two of several projects being conducted through the NIH Roadmap for Medical Research as part of the Human Microbiome Project (HMP) taking place at institutions across the country. NYU Langone Medical Center
The Human Microbiome Project has awarded more than $42 million to expand its exploration of how the trillions of microscopic organisms that live in or on our bodies affect our health, including $1 million to
’s study of GERD progression. Dr. Pei
The esophagus isn't merely a tube for food traveling from the mouth to the stomach, it also provides an environment for bacteria to live, according to a new study by NYU School of Medicine scientists that overturns the general belief that the esophagus is free of bacteria.